myristoleoylcarnitine (c14:1)* to 3-hydroxymyristate

Numerator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Denominator Metabolite

Structure of 3-hydroxymyristate
Metabolite Accession: GCST90199674
Name: 3-hydroxymyristate
Hmdb Id: HMDB0061656,HMDB0010731
Super Pathway: NA
Sub Pathway: NA
Inchikey: ATRNZOYKSNPPBF

Associated Genomic Regions

Region: rs2130525

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.106
Position:
151902101
SE (Ratio):
0.013
Effect Allele:
T
Z-score (Ratio):
8.089
Reference Allele:
C
-log10(P):
-35.044
MAF:
0.392
Beta (Num):
0.040
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.066
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, lipopolysaccharide metabolism.5[1], 6[2]

Ratio Explanation:

The ratio may reflect the balance between fatty acid oxidation and biosynthesis; however, a direct enzymatic link with THEM4 is not established.

Ratio Evidence:

metabolites unrelated

Gene Ratio Phenotype Relationship:

No direct link between THEM4, the specific metabolite ratio, and a phenotype can be established from the provided information.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data