myristoleoylcarnitine (c14:1)* to 3-hydroxyoctanoate

Numerator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Denominator Metabolite

Structure of 3-hydroxyoctanoate
Metabolite Accession: GCST90199680
Name: 3-hydroxyoctanoate
Hmdb Id: HMDB0001954
Super Pathway: NA
Sub Pathway: NA
Inchikey: NDPLAKGOSZHTPH

Associated Genomic Regions

Region: rs6695324

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.165
Position:
151926762
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
10.291
Reference Allele:
A
-log10(P):
-55.517
MAF:
0.316
Beta (Num):
0.048
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.116
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
S100A10 THEM4 S100A11 THEM5 C2CD4D

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid oxidation, carnitine shuttle.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Ratio Explanation:

The ratio of myristoleoylcarnitine to 3-hydroxyoctanoate likely reflects mitochondrial fatty acid oxidation efficiency, potentially modulated by THEM4's thioesterase activity on acyl-CoA substrates.3[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype was provided. The eQTL colocalization suggests THEM4 expression levels influence the ratio of myristoleoylcarnitine to 3-hydroxyoctanoate, reflecting changes in mitochondrial fatty acid oxidation, but a link to a specific phenotype cannot be established with the available data.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data