myristoleoylcarnitine (c14:1)* to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs2130525

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
0.109
Position:
151902101
SE (Ratio):
0.012
Effect Allele:
T
Z-score (Ratio):
8.882
Reference Allele:
C
-log10(P):
-41.870
MAF:
0.392
Beta (Num):
0.040
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.069
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, beta-oxidation.4[1], 5[2], 6[3], 7[4]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, beta-oxidation.8[1], 9[2], 10[3], 11[4], 12[5]

Ratio Explanation:

An increased ratio may indicate altered mitochondrial fatty acid metabolism, potentially influenced by THEM4's thioesterase activity on acyl-CoAs, affecting the balance between these fatty acids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data