myristoleoylcarnitine (c14:1)* to laurylcarnitine

Numerator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Denominator Metabolite

Structure of laurylcarnitine (c12)
Metabolite Accession: GCST90199750
Name: laurylcarnitine (c12)
Hmdb Id: HMDB000225
Super Pathway: NA
Sub Pathway: NA
Inchikey: FUJLYHJROOYKRA

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.085
Position:
102075479
SE (Ratio):
0.011
Effect Allele:
A
Z-score (Ratio):
-7.766
Reference Allele:
G
-log10(P):
-32.448
MAF:
0.176
Beta (Num):
-0.049
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.036
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid desaturation, fatty acid metabolism, carnitine shuttle.1[1], 3[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, carnitine shuttle.4[1], 5[2]

Ratio Explanation:

This ratio of myristoleoylcarnitine (C14:1) to laurylcarnitine (C12:0) likely reflects Stearoyl-CoA Desaturase (SCD) activity, which synthesizes monounsaturated fatty acids like myristoleate (C14:1).1[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in SCD likely alters its activity, changing the myristoleoylcarnitine to laurylcarnitine ratio. This shift in fatty acid desaturation contributes to dyslipidemia, hypercholesterolemia, and increased risk for atherosclerosis and coronary artery disease, which are the associated phenotypes.1[1], 7[2], 8[3]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data