myristoleoylcarnitine (c14:1)* to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs12210538

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.199
Position:
110760008
SE (Ratio):
0.012
Effect Allele:
G
Z-score (Ratio):
16.212
Reference Allele:
A
-log10(P):
-134.434
MAF:
0.239
Beta (Num):
-0.007
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.206
SE (Den):
0.017
No CNV overlap
rQTL cluster:
103
Reaction Distance:
NA
Closest Genes:
SLC22A16 DDO METTL24 CDK19 CDC40

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.7[1], 4[2], 6[3]

Ratio Explanation:

This ratio reflects the relative transport and metabolism of medium-chain (C14:1) versus long-chain (C18:1) fatty acids, potentially modulated by SLC22A16 transporter function.8[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The `SLC22A16` variant likely alters acylcarnitine transport, impacting fatty acid oxidation.1[1] This metabolic dysregulation can influence glucose homeostasis (HbA1c) and erythrocyte membrane integrity, affecting red blood cell indices like MCV and turnover (Total Bilirubin).9[2], 10[3]

Phenotype Driver:

Gene-centric:SLC22A16

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data