myristoleoylcarnitine (c14:1)* to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs603424

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Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
0.082
Position:
102075479
SE (Ratio):
0.009
Effect Allele:
A
Z-score (Ratio):
9.216
Reference Allele:
G
-log10(P):
-44.922
MAF:
0.176
Beta (Num):
-0.049
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.130
SE (Den):
0.019
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

Region: rs6536365

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Clumped rQTL variant

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SNP Summary

Chr:
4
Beta (Ratio):
-0.056
Position:
159632293
SE (Ratio):
0.007
Effect Allele:
A
Z-score (Ratio):
-7.617
Reference Allele:
C
-log10(P):
-31.284
MAF:
0.295
Beta (Num):
-0.055
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.001
SE (Den):
0.016
No CNV overlap
rQTL cluster:
118
Reaction Distance:
NA
Closest Genes:
PPID ETFDH C4orf46 RXFP1 FNIP2

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/oxidation

Denominator Metabolite Explanation:

Fatty acid biosynthesis/oxidation

Ratio Explanation:

The ratio reflects Stearoyl-CoA Desaturase (SCD) activity, which synthesizes palmitoleate (precursor to c16:1) and myristoleate (precursor to c14:1) from their saturated fatty acid precursors.1[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered SCD activity, indicated by the myristoleoylcarnitine/palmitoleoylcarnitine ratio, is linked to dyslipidemia and atherosclerosis.1[1], 4[2] This dysregulation of fatty acid metabolism contributes to the development of coronary artery disease, hypercholesterolemia, and myocardial infarction by affecting membrane composition and lipid signaling.1[3], 4[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data