myristoleoylcarnitine (c14:1)* to stearate (18:0)

Numerator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs603424

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
10
Beta (Ratio):
-0.145
Position:
102075479
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
-7.662
Reference Allele:
G
-log10(P):
-31.633
MAF:
0.176
Beta (Num):
-0.049
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
0.097
SE (Den):
0.020
No CNV overlap
rQTL cluster:
67
Reaction Distance:
NA
Closest Genes:
PKD2L1 BLOC1S2 SCD CWF19L1 CHUK

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Metabolism

Denominator Metabolite Explanation:

Fatty Acid Biosynthesis

Ratio Explanation:

This ratio reflects SCD enzyme activity; higher levels indicate increased desaturation of myristoyl-CoA relative to the availability of the stearate precursor, affecting lipid composition.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The SCD gene influences the ratio of myristoleoylcarnitine to stearate, which is associated with coronary atherosclerosis and hypercholesterolemia, likely through its role in lipid metabolism and its impact on the development of atherosclerotic plaques.1[1], 2[2], 3[3], 4[4]

Phenotype Driver:

Gene-centric:SCD

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data