sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)* to 1-arachidonylglycerol (20:4)

Numerator Metabolite

Metabolite Accession: GCST90199995
Name: sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-arachidonylglycerol (20:4)
Metabolite Accession: GCST90199770
Name: 1-arachidonylglycerol (20:4)
Hmdb Id: HMDB0011578
Super Pathway: NA
Sub Pathway: NA
Inchikey: DCPCOKIYJYGMDN

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.452
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
21.124
Reference Allele:
A
-log10(P):
-226.398
MAF:
0.343
Beta (Num):
0.181
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.271
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Endocannabinoid synthesis, Glycerophospholipid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects the balance between sphingolipid and endocannabinoid pathways, potentially influenced by FADS activity on shared polyunsaturated fatty acid precursors.9[1], 10[2], 11[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter fatty acid desaturation, affecting the balance of pro-inflammatory and anti-inflammatory lipid mediators, which contributes to the risk of cholelithiasis and type 2 diabetes.12[1], 13[2], 14[3], 15[4], 16[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data