sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)* to linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*

Numerator Metabolite

Metabolite Accession: GCST90199995
Name: sphingomyelin (d18:1/20:2, d18:2/20:1, d16:1/22:2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*
Metabolite Accession: GCST90200109
Name: linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*
Hmdb Id: HMDB0007257
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRECEGQUDDMNAQ

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.510
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
22.254
Reference Allele:
C
-log10(P):
-250.945
MAF:
0.339
Beta (Num):
0.186
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.324
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerolipid metabolism, fatty acid desaturation.6[1], 3[2]

Ratio Explanation:

The ratio reflects the balance between sphingolipid synthesis and the production of long-chain polyunsaturated fatty acids, regulated by FADS enzymes.1[1], 2[2], 7[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid levels, impacting inflammatory and metabolic conditions like dyslipidemia, type 2 diabetes, and asthma.8[1], 9[2], 10[3], 11[4] The ratio reflects this altered lipid metabolism, which is linked to various associated inflammatory and metabolic phenotypes.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data