sphingomyelin (d18:1/20:1, d18:2/20:0)* to 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*

Numerator Metabolite

Metabolite Accession: GCST90199996
Name: sphingomyelin (d18:1/20:1, d18:2/20:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200077
Name: 1-stearoyl-2-oleoyl-gpi (18:0/18:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs28456

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.260
Position:
61589481
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
-10.797
Reference Allele:
A
-log10(P):
-60.906
MAF:
0.309
Beta (Num):
-0.138
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.122
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

GPI anchor biosynthesis.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects the balance between sphingolipid and GPI anchor synthesis. FADS1's role in providing fatty acids may influence the acylation of both metabolites.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1 variants impact PUFA levels, influencing susceptibility to inflammatory conditions like asthma and affecting cholesterol metabolism.3[1], 9[2], 10[3], 11[4], 12[5] The ratio may reflect a shift in lipid composition predisposing to these phenotypes.

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data