behenoyl sphingomyelin (d18:1/22:0)* to behenoyl dihydrosphingomyelin (d18:0/22:0)*

Numerator Metabolite

Structure of behenoyl sphingomyelin (d18:1/22:0)*
Metabolite Accession: GCST90199997
Name: behenoyl sphingomyelin (d18:1/22:0)*
Hmdb Id: HMDB0012103
Super Pathway: NA
Sub Pathway: NA
Inchikey: FJJANLYCZUNFSE

Denominator Metabolite

Structure of behenoyl dihydrosphingomyelin (d18:0/22:0)*
Metabolite Accession: GCST90200059
Name: behenoyl dihydrosphingomyelin (d18:0/22:0)*
Hmdb Id: HMDB0012091
Super Pathway: NA
Sub Pathway: NA
Inchikey: FONAXCRWZQFJHY

Associated Genomic Regions

Region: rs17101394

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
0.161
Position:
64232386
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
7.714
Reference Allele:
G
-log10(P):
-32.036
MAF:
0.165
Beta (Num):
0.063
Novel Locus:
Yes ✔️
SE (Num):
0.020
Beta (Den):
-0.098
SE (Den):
0.020
No CNV overlap
rQTL cluster:
47
Reaction Distance:
NA
Closest Genes:
SGPP1 SYNE2 WDR89 PPP2R5E ESR2

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Sphingolipid metabolism.7[1], 8[2]

Ratio Explanation:

The ratio reflects the conversion of behenoyl dihydrosphingomyelin to behenoyl sphingomyelin, a desaturation step in sphingolipid synthesis, potentially influenced by SGPP1's role in the broader pathway.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Alterations in sphingolipid metabolism, potentially influenced by SGPP1 activity, can affect HbA1c and triglyceride levels.9[1], 10[2] Sphingolipids are linked to insulin resistance and dyslipidemia, providing a plausible connection between the metabolic ratio and the observed phenotypes of elevated HbA1c and triglycerides.11[3], 12[4], 13[5]

Phenotype Driver:

Metabolite-centric[both]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data