p-cresol glucuronide* to p-cresol sulfate

Numerator Metabolite

Structure of p-cresol glucuronide*
Metabolite Accession: GCST90200003
Name: p-cresol glucuronide*
Hmdb Id: HMDB0011686
Super Pathway: NA
Sub Pathway: NA
Inchikey: JPAUCQAJHLSMQW

Denominator Metabolite

Structure of p-cresol sulfate
Metabolite Accession: GCST90199740
Name: p-cresol sulfate
Hmdb Id: HMDB0011635
Super Pathway: NA
Sub Pathway: NA
Inchikey: WGNAKZGUSRVWRH

Associated Genomic Regions

Region: rs143647521

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
0.497
Position:
28555161
SE (Ratio):
0.050
Effect Allele:
T
Z-score (Ratio):
9.940
Reference Allele:
C
-log10(P):
-51.935
MAF:
0.010
Beta (Num):
0.370
Novel Locus:
Yes ✔️
SE (Num):
0.076
Beta (Den):
-0.128
SE (Den):
0.074
No CNV overlap
rQTL cluster:
176
Reaction Distance:
NA
Closest Genes:
NUPR1 CCDC101 IL27 APOBR SULT1A2

Region: rs17863784

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Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.209
Position:
234607005
SE (Ratio):
0.021
Effect Allele:
A
Z-score (Ratio):
10.105
Reference Allele:
G
-log10(P):
-53.599
MAF:
0.061
Beta (Num):
0.214
Novel Locus:
No
SE (Num):
0.031
Beta (Den):
0.005
SE (Den):
0.031
No CNV overlap
rQTL cluster:
137
Reaction Distance:
NA
Closest Genes:
UGT1A10 UGT1A8 UGT1A6 UGT1A7 UGT1A9

LLM Analysis

Numerator Metabolite Explanation:

Glucuronidation, Xenobiotic Metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Sulfation, Xenobiotic Metabolism.6[1], 7[2]

Ratio Explanation:

This ratio indicates the balance between competing detoxification pathways for p-cresol: glucuronidation (numerator) versus sulfation (denominator), reflecting relative UGT and SULT enzyme activities.8[1], 6[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the SULT1A locus influences p-cresol sulfation efficiency. This may alter total bilirubin via competition for shared UGT conjugation pathways and total cholesterol, a link supported by colocalization with the APOBR gene.10[1], 11[2]

Phenotype Driver:

Gene-centric:APOBR

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data