p-cresol glucuronide* to phenylacetylglutamine

Numerator Metabolite

Structure of p-cresol glucuronide*
Metabolite Accession: GCST90200003
Name: p-cresol glucuronide*
Hmdb Id: HMDB0011686
Super Pathway: NA
Sub Pathway: NA
Inchikey: JPAUCQAJHLSMQW

Denominator Metabolite

Structure of phenylacetylglutamine
Metabolite Accession: GCST90199768
Name: phenylacetylglutamine
Hmdb Id: HMDB0006344
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFLIEFSWGNOPJJ

Associated Genomic Regions

Region: rs79983684

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.254
Position:
234636401
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
11.310
Reference Allele:
T
-log10(P):
-66.616
MAF:
0.059
Beta (Num):
0.211
Novel Locus:
No
SE (Num):
0.032
Beta (Den):
-0.043
SE (Den):
0.031
No CNV overlap
rQTL cluster:
137
Reaction Distance:
NA
Closest Genes:
UGT1A8 UGT1A10 UGT1A5 UGT1A9 UGT1A7

LLM Analysis

Numerator Metabolite Explanation:

Glucuronidation, Xenobiotic metabolism2[1], 6[2]

Denominator Metabolite Explanation:

Phenylalanine metabolism7[1], 8[2], 9[3], 10[4]

Ratio Explanation:

The ratio reflects UGT1A-mediated p-cresol glucuronidation efficiency relative to phenylacetate conjugation, a separate detoxification pathway for aromatic compounds.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in the UGT1A locus pleiotropically affects the glucuronidation of both p-cresol (numerator) and bilirubin (phenotype), explaining their association.11[1], 12[2], 13[3], 14[4], 15[5] The cholesterol link is less direct but may involve related hepatic pathways.

Phenotype Driver:

Gene-centric:UGT1A

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data