p-cresol glucuronide* to 4-methylcatechol sulfate

Numerator Metabolite

Structure of p-cresol glucuronide*
Metabolite Accession: GCST90200003
Name: p-cresol glucuronide*
Hmdb Id: HMDB0011686
Super Pathway: NA
Sub Pathway: NA
Inchikey: JPAUCQAJHLSMQW

Denominator Metabolite

Structure of 4-methylcatechol sulfate
Metabolite Accession: GCST90199939
Name: 4-methylcatechol sulfate
Hmdb Id: HMDB0240459
Super Pathway: NA
Sub Pathway: NA
Inchikey: NCOMUGOPQPRVSE

Associated Genomic Regions

Region: rs116727752

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
2
Beta (Ratio):
0.322
Position:
234575216
SE (Ratio):
0.033
Effect Allele:
T
Z-score (Ratio):
9.698
Reference Allele:
G
-log10(P):
-49.529
MAF:
0.060
Beta (Num):
0.222
Novel Locus:
No
SE (Num):
0.031
Beta (Den):
-0.100
SE (Den):
0.032
No CNV overlap
rQTL cluster:
137
Reaction Distance:
NA
Closest Genes:
UGT1A10 UGT1A8 UGT1A9 UGT1A7 UGT1A6

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic Metabolism, Glucuronidation.3[1], 4[2]

Denominator Metabolite Explanation:

Xenobiotic Metabolism, Sulfation.5[1], 6[2]

Ratio Explanation:

The ratio reflects the relative activity of two major phase II detoxification pathways: glucuronidation (numerator) and sulfation (denominator) for aromatic compounds from gut metabolism.7[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in UGT1A genes alters glucuronidation efficiency. This directly impacts both p-cresol glucuronide formation (the ratio numerator) and bilirubin conjugation, providing a causal link between the gene, the ratio, and the total bilirubin phenotype, a known consequence of UGT1A1 dysfunction.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:UGT1A

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data