p-cresol glucuronide* to 5-hydroxyindole sulfate

Numerator Metabolite

Structure of p-cresol glucuronide*
Metabolite Accession: GCST90200003
Name: p-cresol glucuronide*
Hmdb Id: HMDB0011686
Super Pathway: NA
Sub Pathway: NA
Inchikey: JPAUCQAJHLSMQW

Denominator Metabolite

Metabolite Accession: GCST90200050
Name: 5-hydroxyindole sulfate
Hmdb Id: HMDB0341278
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs143647521

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
1.037
Position:
28555161
SE (Ratio):
0.120
Effect Allele:
T
Z-score (Ratio):
8.621
Reference Allele:
C
-log10(P):
-39.557
MAF:
0.010
Beta (Num):
0.370
Novel Locus:
Yes ✔️
SE (Num):
0.076
Beta (Den):
-0.667
SE (Den):
0.105
No CNV overlap
rQTL cluster:
176
Reaction Distance:
NA
Closest Genes:
NUPR1 CCDC101 IL27 APOBR SULT1A2

LLM Analysis

Numerator Metabolite Explanation:

P-cresol glucuronidation, xenobiotic metabolism.7[1], 8[2], 9[3]

Denominator Metabolite Explanation:

Serotonin metabolism, sulfation pathway.10[1], 11[2], 12[3]

Ratio Explanation:

The ratio reflects the balance between UGT-mediated glucuronidation of p-cresol and SULT1A1-mediated sulfation of 5-hydroxyindole, representing competing detoxification pathways for gut-derived metabolites.9[1], 10[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SULT1A1 activity, indicated by the ratio, likely impairs sulfation of substrates like bilirubin and bile acids, contributing to elevated total bilirubin and increased cholelithiasis risk. This links the gene, metabolic ratio, and observed phenotypes.13[1], 14[2]

Phenotype Driver:

Gene-centric:SULT1A1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data