3-hydroxyhexanoate to 3-hydroxydodecanedioate*

Numerator Metabolite

Structure of 3-hydroxyhexanoate
Metabolite Accession: GCST90200012
Name: 3-hydroxyhexanoate
Hmdb Id: HMDB0061652,HMDB0010718
Super Pathway: NA
Sub Pathway: NA
Inchikey: HPMGFDVTYHWBAG

Denominator Metabolite

Structure of 3-hydroxydodecanedioate*
Metabolite Accession: GCST90199769
Name: 3-hydroxydodecanedioate*
Hmdb Id: HMDB0000413
Super Pathway: NA
Sub Pathway: NA
Inchikey: FYVQCLGZFXHEGL

Associated Genomic Regions

Region: rs57025390

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
0.186
Position:
47412477
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
8.311
Reference Allele:
C
-log10(P):
-36.897
MAF:
0.123
Beta (Num):
0.049
Novel Locus:
Yes ✔️
SE (Num):
0.023
Beta (Den):
-0.138
SE (Den):
0.025
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4Z1 CYP4B1 CYP4A22

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, polyhydroxyalkanoate biosynthesis. 6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation, dicarboxylic acid metabolism. 5[1], 8[2]

Ratio Explanation:

This ratio may reflect the balance between medium-chain fatty acid beta-oxidation and the omega-oxidation of longer-chain dicarboxylic acids, processes potentially influenced by CYP450 enzymes. 4[1], 8[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided, so a link between the gene, metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data