3-hydroxyhexanoate to hexadecanedioate (c16-dc)

Numerator Metabolite

Structure of 3-hydroxyhexanoate
Metabolite Accession: GCST90200012
Name: 3-hydroxyhexanoate
Hmdb Id: HMDB0061652,HMDB0010718
Super Pathway: NA
Sub Pathway: NA
Inchikey: HPMGFDVTYHWBAG

Denominator Metabolite

Structure of hexadecanedioate (c16-dc)
Metabolite Accession: GCST90199807
Name: hexadecanedioate (c16-dc)
Hmdb Id: HMDB0000672
Super Pathway: NA
Sub Pathway: NA
Inchikey: QQHJDPROMQRDLA

Associated Genomic Regions

Region: rs4149056

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
12
Beta (Ratio):
-0.546
Position:
21331549
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-26.861
Reference Allele:
T
-log10(P):
-364.274
MAF:
0.156
Beta (Num):
-0.030
Novel Locus:
No
SE (Num):
0.021
Beta (Den):
0.516
SE (Den):
0.020
No CNV overlap
rQTL cluster:
52
Reaction Distance:
NA
Closest Genes:
SLCO1B1 RP11-125O5.2 SLCO1B7 SLCO1A2 LST3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid omega-oxidation4[1], 5[2], 6[3]

Ratio Explanation:

Reduced SLCO1B1 function may alter the hepatic uptake of 3-hydroxyhexanoate and hexadecanedioate, impacting fatty acid metabolism and influencing their circulating ratio.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLCO1B1 function, associated with the variant, can impair hepatic clearance of various substrates, leading to phenotypes like hyperbilirubinemia and affecting drug metabolism, which is linked to coronary atherosclerosis and cardiac arrhythmias.7[1], 8[2], 9[3]

Phenotype Driver:

Gene-centric:SLCO1B1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data