3-hydroxyhexanoate to glutamine conjugate of c6h10o2 (2)*

Numerator Metabolite

Structure of 3-hydroxyhexanoate
Metabolite Accession: GCST90200012
Name: 3-hydroxyhexanoate
Hmdb Id: HMDB0061652,HMDB0010718
Super Pathway: NA
Sub Pathway: NA
Inchikey: HPMGFDVTYHWBAG

Denominator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs57674198

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.143
Position:
151876073
SE (Ratio):
0.014
Effect Allele:
C
Z-score (Ratio):
-10.202
Reference Allele:
T
-log10(P):
-54.597
MAF:
0.291
Beta (Num):
-0.080
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.062
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.4[1]

Denominator Metabolite Explanation:

Partially Characterized Metabolite.5[1], 6[2]

Ratio Explanation:

The ratio likely reflects alterations in fatty acid metabolism, where THEM4's thioesterase activity could influence the levels of 3-hydroxyhexanoate and its subsequent conjugation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

THEM4's role in lipid metabolism and inflammation may link to diverticular disease.1[1], 7[2] Altered fatty acid metabolism, reflected by the ratio, could contribute to the low-grade inflammation observed in this condition.7[3]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data