3-hydroxyhexanoate to 3-hydroxybutyroylglycine**

Numerator Metabolite

Structure of 3-hydroxyhexanoate
Metabolite Accession: GCST90200012
Name: 3-hydroxyhexanoate
Hmdb Id: HMDB0061652,HMDB0010718
Super Pathway: NA
Sub Pathway: NA
Inchikey: HPMGFDVTYHWBAG

Denominator Metabolite

Metabolite Accession: GCST90200174
Name: 3-hydroxybutyroylglycine**
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs28415528

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.136
Position:
151879761
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-7.995
Reference Allele:
G
-log10(P):
-34.281
MAF:
0.318
Beta (Num):
-0.078
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.058
SE (Den):
0.016
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

Region: rs640777

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.148
Position:
67354986
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-9.309
Reference Allele:
C
-log10(P):
-45.792
MAF:
0.425
Beta (Num):
-0.046
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.101
SE (Den):
0.015
No CNV overlap
rQTL cluster:
58
Reaction Distance:
NA
Closest Genes:
GSTP1 C11orf72 NDUFV1 NUDT8 TBX10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism

Denominator Metabolite Explanation:

Fatty Acid Metabolism (Acyl Glycine)4[1], 5[2]

Ratio Explanation:

The ratio may reflect altered fatty acid metabolism, where THEM4 could influence the balance between different fatty acid derivatives.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered THEM4 activity may disrupt lipid metabolism, reflected in the 3-hydroxyhexanoate to 3-hydroxybutyroylglycine ratio, potentially contributing to cellular stress implicated in glaucoma and affecting red blood cell characteristics.

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data