3-hydroxyhexanoate to glutamine conjugate of c6h10o2 (1)*

Numerator Metabolite

Structure of 3-hydroxyhexanoate
Metabolite Accession: GCST90200012
Name: 3-hydroxyhexanoate
Hmdb Id: HMDB0061652,HMDB0010718
Super Pathway: NA
Sub Pathway: NA
Inchikey: HPMGFDVTYHWBAG

Denominator Metabolite

Metabolite Accession: GCST90200176
Name: glutamine conjugate of c6h10o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs57674198

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.123
Position:
151876073
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-7.859
Reference Allele:
T
-log10(P):
-33.187
MAF:
0.291
Beta (Num):
-0.080
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.043
SE (Den):
0.017
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 THEM5 C2CD4D RORC S100A10

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Xenobiotic metabolism, Fatty acid metabolism

Ratio Explanation:

The ratio reflects the flux of C6-acyl-CoA between mitochondrial beta-oxidation (numerator) and conjugation for clearance (denominator), modulated by THEM4 thioesterase activity.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced THEM4 activity may alter fatty acid metabolism, potentially contributing to the low-grade inflammation and changes in gut microbiota and motility characteristic of diverticular disease.1[1], 2[2], 4[3], 5[4], 6[5]

Phenotype Driver:

Gene-centric:THEM4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data