n-acetylkynurenine (2) to 21-hydroxypregnenolone disulfate

Numerator Metabolite

Structure of n-acetylkynurenine (2)
Metabolite Accession: GCST90200015
Name: n-acetylkynurenine (2)
Hmdb Id: HMDB0240342
Super Pathway: NA
Sub Pathway: NA
Inchikey: PPIMFXHQDQRWGJ

Denominator Metabolite

Structure of 21-hydroxypregnenolone disulfate
Metabolite Accession: GCST90199849
Name: 21-hydroxypregnenolone disulfate
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: CBOVWLYQUCVTFA

Associated Genomic Regions

Region: rs1165195

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.291
Position:
25815080
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-12.725
Reference Allele:
G
-log10(P):
-83.736
MAF:
0.435
Beta (Num):
-0.129
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.162
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Kynurenine pathway (Tryptophan metabolism)7[1], 8[2]

Denominator Metabolite Explanation:

Steroid biosynthesis9[1], 10[2]

Ratio Explanation:

The ratio likely reflects the activity of the SLC17A4 transporter on unrelated metabolites, potentially influencing urate and steroid hormone balance.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 gene's function as a urate transporter directly links it to phenotypes like serum creatinine and uric acid levels.11[1], 6[2], 12[3] Altered transport activity due to the missense variant could impact renal and hematological parameters.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data