n-acetylkynurenine (2) to androstenediol (3beta,17beta) disulfate (2)

Numerator Metabolite

Structure of n-acetylkynurenine (2)
Metabolite Accession: GCST90200015
Name: n-acetylkynurenine (2)
Hmdb Id: HMDB0240342
Super Pathway: NA
Sub Pathway: NA
Inchikey: PPIMFXHQDQRWGJ

Denominator Metabolite

Structure of androstenediol (3beta,17beta) disulfate (2)
Metabolite Accession: GCST90199851
Name: androstenediol (3beta,17beta) disulfate (2)
Hmdb Id: HMDB0240313
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWPTUYJASNIIJM

Associated Genomic Regions

Region: rs1165195

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.219
Position:
25815080
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
-9.863
Reference Allele:
G
-log10(P):
-51.165
MAF:
0.435
Beta (Num):
-0.129
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.091
SE (Den):
0.014
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Numerator Pathway(s): Tryptophan metabolism / Kynurenine pathway.5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Denominator Pathway(s): Androgen and estrogen metabolism.9[1], 10[2], 11[3]

Ratio Explanation:

Ratio Interpretation: SLC17A4 may transport urate and other organic anions, but its direct interaction with n-acetylkynurenine or androstenediol disulfate is not established, making the ratio's meaning unclear.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The transporter SLC17A4 is linked to variations in urate and creatinine, which are measured phenotypes.1[1], 12[2] Hematological traits (MCH, MCHC, Ht, Hb, MCV) may be indirectly affected by kidney function or other systemic effects of SLC17A4 transport activity, though the direct mechanism isn't clear.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data