n-acetylkynurenine (2) to phenylacetylglutamate

Numerator Metabolite

Structure of n-acetylkynurenine (2)
Metabolite Accession: GCST90200015
Name: n-acetylkynurenine (2)
Hmdb Id: HMDB0240342
Super Pathway: NA
Sub Pathway: NA
Inchikey: PPIMFXHQDQRWGJ

Denominator Metabolite

Structure of phenylacetylglutamate
Metabolite Accession: GCST90200069
Name: phenylacetylglutamate
Hmdb Id: HMDB0059772
Super Pathway: NA
Sub Pathway: NA
Inchikey: PTSRBZOZSRJCKX

Associated Genomic Regions

Region: rs11754288

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
6
Beta (Ratio):
-0.294
Position:
25776949
SE (Ratio):
0.025
Effect Allele:
A
Z-score (Ratio):
-11.850
Reference Allele:
G
-log10(P):
-72.922
MAF:
0.419
Beta (Num):
-0.130
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.164
SE (Den):
0.017
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A4 SLC17A1 HIST1H2BA HIST1H2AA SLC17A3

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan metabolism4[1], 5[2]

Denominator Metabolite Explanation:

Phenylalanine metabolism6[1], 7[2], 8[3]

Ratio Explanation:

The ratio may reflect altered transport activity of SLC17A4, a known urate transporter1[1], 2[2], potentially impacting clearance of these amino acid metabolites.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC17A4 function likely affects its transport of diverse substrates, including urate and creatinine, causing the associated renal phenotypes.9[1], 10[2], 11[3] The change in the n-acetylkynurenine to phenylacetylglutamate ratio is likely another consequence of this altered transport activity.

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data