n-acetylkynurenine (2) to hydroxy-cmpf*

Numerator Metabolite

Structure of n-acetylkynurenine (2)
Metabolite Accession: GCST90200015
Name: n-acetylkynurenine (2)
Hmdb Id: HMDB0240342
Super Pathway: NA
Sub Pathway: NA
Inchikey: PPIMFXHQDQRWGJ

Denominator Metabolite

Metabolite Accession: GCST90200154
Name: hydroxy-cmpf*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs1177442

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Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.238
Position:
25809069
SE (Ratio):
0.023
Effect Allele:
A
Z-score (Ratio):
-10.390
Reference Allele:
G
-log10(P):
-56.555
MAF:
0.435
Beta (Num):
-0.128
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.110
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan metabolism (Kynurenine pathway).6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Furanoid acid metabolism; uremic toxin clearance.9[1], 10[2], 11[3]

Ratio Explanation:

The ratio likely reflects altered renal clearance of a tryptophan metabolite versus a uremic toxin, potentially modulated by SLC17A4 transporter activity.12[1], 13[2], 14[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 variant likely alters renal transport, impacting serum levels of N-acetylkynurenine and hydroxy-CMPF; this impaired clearance is reflected in the associated renal (creatinine, uric acid) and hematological phenotypes.13[1], 14[2], 3[3]

Phenotype Driver:

Gene-centric:SLC17A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data