n-acetylkynurenine (2) to 8-methoxykynurenate

Numerator Metabolite

Structure of n-acetylkynurenine (2)
Metabolite Accession: GCST90200015
Name: n-acetylkynurenine (2)
Hmdb Id: HMDB0240342
Super Pathway: NA
Sub Pathway: NA
Inchikey: PPIMFXHQDQRWGJ

Denominator Metabolite

Structure of 8-methoxykynurenate
Metabolite Accession: GCST90200186
Name: 8-methoxykynurenate
Hmdb Id: HMDB0060426
Super Pathway: NA
Sub Pathway: NA
Inchikey: BXZSKDOPGDPDEG

Associated Genomic Regions

Region: rs1177442

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.223
Position:
25809069
SE (Ratio):
0.023
Effect Allele:
A
Z-score (Ratio):
-9.563
Reference Allele:
G
-log10(P):
-48.224
MAF:
0.435
Beta (Num):
-0.128
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.095
SE (Den):
0.017
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A3 SLC17A4 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan metabolism / Kynurenine pathway.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Tryptophan metabolism / Kynurenine pathway.9[1], 10[2], 11[3], 12[4]

Ratio Explanation:

The ratio reflects activity within the kynurenine pathway. The associated gene, SLC17A4, has been identified as a putative transporter for n-acetylkynurenine.13[1], 14[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 missense variant likely alters its function as a urate transporter, directly impacting serum uric acid and creatinine levels.1[1], 15[2], 16[3], 17[4] The altered kynurenine ratio is likely a secondary effect, possibly due to co-transport or downstream consequences of altered renal function on tryptophan metabolism.13[5], 14[6]

Phenotype Driver:

Gene-centric:[SLC17A4]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data