n-acetylkynurenine (2) to decadienedioic acid (c10:2-dc)**

Numerator Metabolite

Structure of n-acetylkynurenine (2)
Metabolite Accession: GCST90200015
Name: n-acetylkynurenine (2)
Hmdb Id: HMDB0240342
Super Pathway: NA
Sub Pathway: NA
Inchikey: PPIMFXHQDQRWGJ

Denominator Metabolite

Structure of decadienedioic acid (c10:2-dc)**
Metabolite Accession: GCST90200700
Name: decadienedioic acid (c10:2-dc)**
Hmdb Id: HMDB0242172
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRWVXIATCBRYHA

Associated Genomic Regions

Region: rs2328895

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
-0.292
Position:
25802083
SE (Ratio):
0.023
Effect Allele:
C
Z-score (Ratio):
-12.549
Reference Allele:
T
-log10(P):
-81.499
MAF:
0.435
Beta (Num):
-0.128
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.164
SE (Den):
0.015
No CNV overlap
rQTL cluster:
111
Reaction Distance:
NA
Closest Genes:
SLC17A1 SLC17A4 SLC17A3 HIST1H2BA HIST1H2AA

LLM Analysis

Numerator Metabolite Explanation:

Tryptophan and kynurenine metabolism.7[1], 8[2], 9[3], 10[4]

Denominator Metabolite Explanation:

Fatty acid omega-oxidation.11[1], 12[2]

Ratio Explanation:

The ratio may indicate a metabolic shift between tryptophan catabolism and fatty acid oxidation, potentially influenced by SLC17A4's role as an organic anion transporter.13[1], 11[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC17A4 gene's primary function in transporting urate directly explains the association with uric acid levels.1[1], 5[2], 14[3] Altered urate homeostasis is linked to kidney function (sCr) and can influence red blood cell parameters (Hb, Ht, MCH, MCHC, MCV).

Phenotype Driver:

Gene-centric:[SLC17A4]

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data