adipoylcarnitine (c6-dc) to glutarylcarnitine (c5-dc)

Numerator Metabolite

Structure of adipoylcarnitine (c6-dc)
Metabolite Accession: GCST90200018
Name: adipoylcarnitine (c6-dc)
Hmdb Id: HMDB0061677
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSVHAXJKBCWVDA

Denominator Metabolite

Structure of glutarylcarnitine (c5-dc)
Metabolite Accession: GCST90199799
Name: glutarylcarnitine (c5-dc)
Hmdb Id: HMDB0013130
Super Pathway: NA
Sub Pathway: NA
Inchikey: NXJAXUYOQLTISD

Associated Genomic Regions

Region: rs1134688

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.493
Position:
53681699
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
22.300
Reference Allele:
T
-log10(P):
-251.973
MAF:
0.228
Beta (Num):
0.245
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.248
SE (Den):
0.018
No CNV overlap
rQTL cluster:
162
Reaction Distance:
NA
Closest Genes:
C1orf123 CPT2 MAGOH LRP8 SLC1A7

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Lysine and tryptophan degradation.6[1], 7[2], 8[3]

Ratio Explanation:

An altered ratio of adipoylcarnitine to glutarylcarnitine may reflect disruption in mitochondrial fatty acid and amino acid metabolism due to impaired CPT2 function.9[1], 10[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype data was provided; therefore, a causal link between the CPT2 variant, the adipoylcarnitine to glutarylcarnitine ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data