adipoylcarnitine (c6-dc) to methylsuccinoylcarnitine

Numerator Metabolite

Structure of adipoylcarnitine (c6-dc)
Metabolite Accession: GCST90200018
Name: adipoylcarnitine (c6-dc)
Hmdb Id: HMDB0061677
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSVHAXJKBCWVDA

Denominator Metabolite

Metabolite Accession: GCST90200089
Name: methylsuccinoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs11578832

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.556
Position:
53674542
SE (Ratio):
0.025
Effect Allele:
A
Z-score (Ratio):
22.560
Reference Allele:
G
-log10(P):
-257.811
MAF:
0.228
Beta (Num):
0.246
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
-0.310
SE (Den):
0.018
No CNV overlap
rQTL cluster:
162
Reaction Distance:
NA
Closest Genes:
CPT2 C1orf123 MAGOH LRP8 SLC1A7

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.4[1]

Denominator Metabolite Explanation:

Branched-chain amino acid catabolism.5[1]

Ratio Explanation:

CPT2 dysfunction leads to broad acylcarnitine profile changes, including adipoylcarnitine; the link to methylsuccinoylcarnitine reflects system-wide metabolic stress rather than a direct pathway interaction.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No phenotype was associated with this ratio; therefore, a causal link between the CPT2 gene, the adipoylcarnitine to methylsuccinoylcarnitine ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data