adipoylcarnitine (c6-dc) to glutamine conjugate of c6h10o2 (2)*

Numerator Metabolite

Structure of adipoylcarnitine (c6-dc)
Metabolite Accession: GCST90200018
Name: adipoylcarnitine (c6-dc)
Hmdb Id: HMDB0061677
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSVHAXJKBCWVDA

Denominator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs11211403

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.277
Position:
47392855
SE (Ratio):
0.025
Effect Allele:
G
Z-score (Ratio):
-11.083
Reference Allele:
T
-log10(P):
-64.059
MAF:
0.124
Beta (Num):
-0.213
Novel Locus:
No
SE (Num):
0.023
Beta (Den):
0.065
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty Acid Omega-Oxidation

Denominator Metabolite Explanation:

Phase II Conjugation6[1]

Ratio Explanation:

The ratio reflects two alternative disposal routes for medium-chain acyl-CoAs that accumulate due to impaired beta-oxidation by the ACADM enzyme.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

No phenotype colocalization was provided, so a direct link between the adipoylcarnitine to glutamine conjugate of C6H10O2 ratio and a specific phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data