adipoylcarnitine (c6-dc) to glycine conjugate of c10h14o2 (1)*

Numerator Metabolite

Structure of adipoylcarnitine (c6-dc)
Metabolite Accession: GCST90200018
Name: adipoylcarnitine (c6-dc)
Hmdb Id: HMDB0061677
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSVHAXJKBCWVDA

Denominator Metabolite

Metabolite Accession: GCST90200175
Name: glycine conjugate of c10h14o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs12132488

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
1
Beta (Ratio):
-0.409
Position:
47389613
SE (Ratio):
0.030
Effect Allele:
T
Z-score (Ratio):
-13.799
Reference Allele:
C
-log10(P):
-98.063
MAF:
0.127
Beta (Num):
-0.209
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.201
SE (Den):
0.023
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Dicarboxylic acid metabolism9[1], 10[2]

Denominator Metabolite Explanation:

Xenobiotic metabolism, Glycine conjugation11[1], 12[2], 13[3]

Ratio Explanation:

A higher ratio may result from decreased CYP4B1-mediated metabolism of a xenobiotic precursor of the denominator, though direct evidence linking CYP4B1 is absent.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype is associated, so no link between the CYP4B1 variant, the metabolic ratio, and a phenotype can be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data