adipoylcarnitine (c6-dc) to glycine conjugate of c10h12o2*

Numerator Metabolite

Structure of adipoylcarnitine (c6-dc)
Metabolite Accession: GCST90200018
Name: adipoylcarnitine (c6-dc)
Hmdb Id: HMDB0061677
Super Pathway: NA
Sub Pathway: NA
Inchikey: BSVHAXJKBCWVDA

Denominator Metabolite

Metabolite Accession: GCST90200182
Name: glycine conjugate of c10h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs12132488

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
-0.354
Position:
47389613
SE (Ratio):
0.031
Effect Allele:
T
Z-score (Ratio):
-11.281
Reference Allele:
C
-log10(P):
-66.285
MAF:
0.127
Beta (Num):
-0.209
Novel Locus:
No
SE (Num):
0.022
Beta (Den):
0.145
SE (Den):
0.026
No CNV overlap
rQTL cluster:
163
Reaction Distance:
NA
Closest Genes:
CYP4A11 CYP4X1 CYP4B1 CYP4Z1 EFCAB14

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid omega-oxidation.8[1], 9[2]

Denominator Metabolite Explanation:

Xenobiotic metabolism, glycine conjugation.10[1], 11[2], 12[3], 13[4]

Ratio Explanation:

The ratio may reflect activity in fatty acid omega-oxidation versus xenobiotic conjugation pathways, but a direct link through CYP4B1 is unlikely given its inactivity.

Ratio Evidence:

metabolites unrelated

Gene Ratio Phenotype Relationship:

No phenotype is provided, so a link between the gene, metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data