lignoceroyl sphingomyelin (d18:1/24:0) to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of lignoceroyl sphingomyelin (d18:1/24:0)
Metabolite Accession: GCST90200020
Name: lignoceroyl sphingomyelin (d18:1/24:0)
Hmdb Id: HMDB0011697
Super Pathway: NA
Sub Pathway: NA
Inchikey: QEDPUVGSSDPBMD

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs4246215

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.188
Position:
61564299
SE (Ratio):
0.019
Effect Allele:
T
Z-score (Ratio):
-9.853
Reference Allele:
G
-log10(P):
-51.061
MAF:
0.353
Beta (Num):
-0.066
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.123
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FEN1 FADS1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.7[1]

Ratio Explanation:

The ratio reflects the balance between a very long-chain saturated sphingolipid and a polyunsaturated glycerophospholipid, potentially modulated by FADS activity on fatty acid precursors.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered FADS activity likely shifts the fatty acid pool, impacting the synthesis of both sphingolipids and glycerophospholipids, contributing to dyslipidemia and inflammatory conditions like asthma and cholelithiasis, which are associated with imbalances in lipid metabolism.8[1], 3[2], 4[3], 9[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data