lignoceroyl sphingomyelin (d18:1/24:0) to 1-linoleoyl-gpi (18:2)*

Numerator Metabolite

Structure of lignoceroyl sphingomyelin (d18:1/24:0)
Metabolite Accession: GCST90200020
Name: lignoceroyl sphingomyelin (d18:1/24:0)
Hmdb Id: HMDB0011697
Super Pathway: NA
Sub Pathway: NA
Inchikey: QEDPUVGSSDPBMD

Denominator Metabolite

Structure of 1-linoleoyl-gpi (18:2)*
Metabolite Accession: GCST90199821
Name: 1-linoleoyl-gpi (18:2)*
Hmdb Id: HMDB0240597
Super Pathway: NA
Sub Pathway: NA
Inchikey: SAHCQBPGXQFTRA

Associated Genomic Regions

Region: rs174535

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.228
Position:
61551356
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
-12.177
Reference Allele:
T
-log10(P):
-76.873
MAF:
0.344
Beta (Num):
-0.065
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.163
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.

Ratio Explanation:

The ratio reflects the balance between sphingolipid and glycerophospholipid synthesis, potentially influenced by FADS activity on fatty acid precursors for both pathways.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, reflected in the ratio, impacts the composition of lipids like sphingolipids and glycerophospholipids.5[1], 6[2] This dysregulation is linked to hypercholesterolemia and cholelithiasis, potentially through effects on membrane fluidity, lipoprotein metabolism, and inflammatory pathways.7[3], 8[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data