linoleoyl ethanolamide to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Structure of linoleoyl ethanolamide
Metabolite Accession: GCST90200029
Name: linoleoyl ethanolamide
Hmdb Id: HMDB0012252
Super Pathway: NA
Sub Pathway: NA
Inchikey: KQXDGUVSAAQARU

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs174535

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.162
Position:
61551356
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
8.990
Reference Allele:
T
-log10(P):
-42.848
MAF:
0.345
Beta (Num):
0.077
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.085
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
10.0
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Endocannabinoid/Fatty acid amide biosynthesis5[1], 6[2]

Denominator Metabolite Explanation:

Omega-3 PUFA metabolism7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects the balance between omega-6 (linoleoyl ethanolamide) and omega-3 (DHA) pathways, which is influenced by FADS1/FADS2 enzyme efficiency.3[1], 4[2], 10[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase efficiency, impacting the balance of pro-inflammatory omega-6 and anti-inflammatory omega-3 derived lipids.11[1], 12[2] This imbalance influences lipid metabolism and inflammatory responses, contributing to cardiometabolic and inflammatory phenotypes like hypercholesterolemia, cholelithiasis, and asthma.3[3], 13[4], 14[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data