linoleoyl ethanolamide to adrenate (22:4n6)

Numerator Metabolite

Structure of linoleoyl ethanolamide
Metabolite Accession: GCST90200029
Name: linoleoyl ethanolamide
Hmdb Id: HMDB0012252
Super Pathway: NA
Sub Pathway: NA
Inchikey: KQXDGUVSAAQARU

Denominator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Associated Genomic Regions

Region: rs174535

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.258
Position:
61551356
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
15.192
Reference Allele:
T
-log10(P):
-118.353
MAF:
0.345
Beta (Num):
0.077
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.181
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis

Denominator Metabolite Explanation:

Polyunsaturated fatty acid metabolism

Ratio Explanation:

The ratio of linoleoyl ethanolamide to adrenate likely reflects the efficiency of converting n-6 fatty acids to long-chain polyunsaturated fatty acids, a process influenced by FADS1 activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1 gene variants are linked to altered lipid metabolism and inflammation, influencing susceptibility to type 2 diabetes, cholelithiasis, and disorders of lipoprotein metabolism, all of which are associated with this ratio.4[1], 5[2], 6[3], 7[4], 8[5], 9[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data