linoleoyl ethanolamide to docosapentaenoate n3 DPA; 22:5n3

Numerator Metabolite

Structure of linoleoyl ethanolamide
Metabolite Accession: GCST90200029
Name: linoleoyl ethanolamide
Hmdb Id: HMDB0012252
Super Pathway: NA
Sub Pathway: NA
Inchikey: KQXDGUVSAAQARU

Denominator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Associated Genomic Regions

Region: rs174535

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.219
Position:
61551356
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
13.279
Reference Allele:
T
-log10(P):
-90.982
MAF:
0.345
Beta (Num):
0.077
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.142
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Endocannabinoid signaling.4[1], 5[2]

Denominator Metabolite Explanation:

Omega-3 fatty acid biosynthesis.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio may represent the balance between endocannabinoid degradation and polyunsaturated fatty acid synthesis, with a higher ratio suggesting reduced FAAH activity or FADS pathway flux.1[1], 8[2], 9[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

A missense variant in FAAH and eQTL colocalization for FADS1/FADS2 suggest a genetic predisposition to altered lipid metabolism. This may influence the risk for cholelithiasis and hypercholesterolemia, conditions linked to disturbances in fatty acid and endocannabinoid pathways which affect inflammation and cholesterol homeostasis.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data