linoleoyl ethanolamide to stearidonate (18:4n3)

Numerator Metabolite

Structure of linoleoyl ethanolamide
Metabolite Accession: GCST90200029
Name: linoleoyl ethanolamide
Hmdb Id: HMDB0012252
Super Pathway: NA
Sub Pathway: NA
Inchikey: KQXDGUVSAAQARU

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs174536

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.199
Position:
61551927
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
11.147
Reference Allele:
A
-log10(P):
-64.772
MAF:
0.342
Beta (Num):
0.079
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.120
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Endocannabinoid/Fatty Acid Metabolism3[1], 4[2]

Denominator Metabolite Explanation:

Omega-3 Fatty Acid Metabolism5[1], 6[2]

Ratio Explanation:

The ratio reflects the balance of FADS2 activity on linoleic acid (n-6) versus alpha-linolenic acid (n-3) precursors, key in PUFA biosynthesis.1[1], 7[2], 2[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS gene cluster alters the balance of n-3 and n-6 PUFA synthesis.1[1], 8[2] This dysregulation impacts lipid levels and inflammation, contributing to phenotypes like hypercholesterolemia, cholelithiasis, and asthma.9[3], 10[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data