linoleoyl ethanolamide to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of linoleoyl ethanolamide
Metabolite Accession: GCST90200029
Name: linoleoyl ethanolamide
Hmdb Id: HMDB0012252
Super Pathway: NA
Sub Pathway: NA
Inchikey: KQXDGUVSAAQARU

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174536

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.192
Position:
61551927
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
10.295
Reference Allele:
A
-log10(P):
-55.563
MAF:
0.342
Beta (Num):
0.079
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.113
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis5[1]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis6[1], 7[2]

Ratio Explanation:

This ratio reflects the activity of FADS1/FADS2 enzymes, where lower activity leads to an accumulation of the precursor linoleoyl ethanolamide and lower levels of downstream docosapentaenoate.8[1], 6[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by an increased linoleoyl ethanolamide to docosapentaenoate ratio, alters lipid profiles, potentially contributing to cholelithiasis and dyslipidemia, phenotypes associated with this genetic locus.3[1], 10[2], 11[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data