linoleoyl ethanolamide to dihomo-linolenate (20:3n3 or n6)

Numerator Metabolite

Structure of linoleoyl ethanolamide
Metabolite Accession: GCST90200029
Name: linoleoyl ethanolamide
Hmdb Id: HMDB0012252
Super Pathway: NA
Sub Pathway: NA
Inchikey: KQXDGUVSAAQARU

Denominator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Associated Genomic Regions

Region: rs324420

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.236
Position:
46870761
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
12.886
Reference Allele:
C
-log10(P):
-85.814
MAF:
0.216
Beta (Num):
0.224
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.012
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

Region: rs11644601

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Clumped rQTL variant

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SNP Summary

Chr:
16
Beta (Ratio):
-0.144
Position:
15172118
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-8.631
Reference Allele:
T
-log10(P):
-39.641
MAF:
0.291
Beta (Num):
-0.045
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
0.098
SE (Den):
0.016
No CNV overlap
rQTL cluster:
34
Reaction Distance:
NA
Closest Genes:
PDXDC1 RRN3 NTAN1 NPIPA1 NOMO1

LLM Analysis

Numerator Metabolite Explanation:

N-acylethanolamine / Endocannabinoid metabolism.4[1], 7[2]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid (PUFA) biosynthesis.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio reflects FAAH activity; decreased FAAH function elevates the numerator (linoleoyl ethanolamide), altering its balance with downstream or related fatty acids like dihomo-linolenate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced FAAH activity, indicated by the elevated ratio, is associated with changes in lipid profiles.5[1], 11[2] Altered endocannabinoid signaling due to FAAH variants can influence lipid homeostasis, affecting HDL and triglyceride levels, which are known cardiometabolic risk factors.5[3], 12[4], 11[5]

Phenotype Driver:

Gene-centric:FAAH

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data