linoleoyl ethanolamide to stearate (18:0)

Numerator Metabolite

Structure of linoleoyl ethanolamide
Metabolite Accession: GCST90200029
Name: linoleoyl ethanolamide
Hmdb Id: HMDB0012252
Super Pathway: NA
Sub Pathway: NA
Inchikey: KQXDGUVSAAQARU

Denominator Metabolite

Structure of stearate (18:0)
Metabolite Accession: GCST90200390
Name: stearate (18:0)
Hmdb Id: HMDB0000827
Super Pathway: NA
Sub Pathway: NA
Inchikey: QIQXTHQIDYTFRH

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.255
Position:
46870761
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
13.574
Reference Allele:
C
-log10(P):
-94.969
MAF:
0.216
Beta (Num):
0.224
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.032
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Numerator Pathway(s): N-acylethanolamine biosynthesis.7[1], 8[2]

Denominator Metabolite Explanation:

Denominator Pathway(s): Fatty acid biosynthesis, elongation.9[1], 10[2]

Ratio Explanation:

Ratio Interpretation: The ratio of linoleoyl ethanolamide to stearate reflects FAAH activity; reduced FAAH function increases the numerator while the denominator is largely unaffected by this enzyme.

Ratio Evidence:

Ratio Evidence Level: metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Ratio-Phenotype Link: No FinnGen or BioBank Japan phenotype associations are provided. The FAAH variant is linked to altered endocannabinoid signaling, potentially impacting responses to stress and addiction.1[1], 2[2], 11[3]

Phenotype Driver:

Primary Driver Of Phenotype Link: none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data