linoleoyl ethanolamide to palmitate (16:0)

Numerator Metabolite

Structure of linoleoyl ethanolamide
Metabolite Accession: GCST90200029
Name: linoleoyl ethanolamide
Hmdb Id: HMDB0012252
Super Pathway: NA
Sub Pathway: NA
Inchikey: KQXDGUVSAAQARU

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.245
Position:
46870761
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
13.077
Reference Allele:
C
-log10(P):
-88.303
MAF:
0.216
Beta (Num):
0.224
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.022
SE (Den):
0.018
No CNV overlap
rQTL cluster:
164
Reaction Distance:
3.0
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

N-acylethanolamine biosynthesis7[1], 8[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis; Lipogenesis9[1], 10[2], 11[3]

Ratio Explanation:

Increased ratio suggests decreased FAAH activity, leading to less degradation of linoleoyl ethanolamide, a fatty acid amide, relative to palmitate production.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No associated phenotype was provided, so no link can be established between the gene, the metabolic ratio, and a phenotype.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data