linoleoyl ethanolamide to margarate (17:0)

Numerator Metabolite

Structure of linoleoyl ethanolamide
Metabolite Accession: GCST90200029
Name: linoleoyl ethanolamide
Hmdb Id: HMDB0012252
Super Pathway: NA
Sub Pathway: NA
Inchikey: KQXDGUVSAAQARU

Denominator Metabolite

Structure of margarate (17:0)
Metabolite Accession: GCST90200459
Name: margarate (17:0)
Hmdb Id: HMDB0002259
Super Pathway: NA
Sub Pathway: NA
Inchikey: KEMQGTRYUADPNZ

Associated Genomic Regions

Region: rs324420

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.242
Position:
46870761
SE (Ratio):
0.019
Effect Allele:
A
Z-score (Ratio):
12.771
Reference Allele:
C
-log10(P):
-84.330
MAF:
0.216
Beta (Num):
0.224
Novel Locus:
No
SE (Num):
0.019
Beta (Den):
-0.019
SE (Den):
0.019
No CNV overlap
rQTL cluster:
164
Reaction Distance:
NA
Closest Genes:
FAAH NSUN4 UQCRH LRRC41 DMBX1

LLM Analysis

Numerator Metabolite Explanation:

Endocannabinoid metabolism, fatty acid amide hydrolysis.8[1], 9[2], 10[3], 11[4]

Denominator Metabolite Explanation:

Fatty acid metabolism (exogenous/ruminant origin).12[1], 13[2], 14[3]

Ratio Explanation:

The ratio likely reflects FAAH catabolic activity on linoleoyl ethanolamide, as a less functional FAAH would increase the numerator, while the denominator, margarate, is biologically unrelated.4[1], 15[2], 13[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

No phenotype association was provided; therefore, a causal link between the FAAH variant, the metabolite ratio, and a phenotype cannot be established.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data