1,2-dilinoleoyl-gpc (18:2/18:2) to 1-lignoceroyl-gpc (24:0)

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpc (18:2/18:2)
Metabolite Accession: GCST90200030
Name: 1,2-dilinoleoyl-gpc (18:2/18:2)
Hmdb Id: HMDB0008138
Super Pathway: NA
Sub Pathway: NA
Inchikey: FVXDQWZBHIXIEJ

Denominator Metabolite

Metabolite Accession: GCST90199895
Name: 1-lignoceroyl-gpc (24:0)
Hmdb Id: HMDB0010405
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.418
Position:
61557803
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
25.373
Reference Allele:
T
-log10(P):
-325.348
MAF:
0.347
Beta (Num):
0.288
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis1[1], 8[2]

Denominator Metabolite Explanation:

Fatty acid metabolism9[1]

Ratio Explanation:

The ratio of 1,2-dilinoleoyl-GPC to 1-lignoceroyl-GPC may reflect the balance between polyunsaturated and saturated fatty acid metabolism, influenced by FADS1/FADS2 activity.1[1], 2[2], 3[3], 10[4], 5[5]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 gene variants influence the metabolism of polyunsaturated fatty acids.3[1], 10[2], 5[3], 11[4] Dysregulation of this process is associated with altered lipid profiles, including cholesterol levels, and an increased risk for inflammatory conditions, Type 2 diabetes, and cholelithiasis.12[5], 13[6], 14[7], 15[8], 16[9], 17[10]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data