1,2-dilinoleoyl-gpc (18:2/18:2) to 1-(1-enyl-palmitoyl)-gpc (p-16:0)*

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpc (18:2/18:2)
Metabolite Accession: GCST90200030
Name: 1,2-dilinoleoyl-gpc (18:2/18:2)
Hmdb Id: HMDB0008138
Super Pathway: NA
Sub Pathway: NA
Inchikey: FVXDQWZBHIXIEJ

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Metabolite Accession: GCST90199899
Name: 1-(1-enyl-palmitoyl)-gpc (p-16:0)*
Hmdb Id: HMDB0010407
Super Pathway: NA
Sub Pathway: NA
Inchikey: HTZINLFNXLXRBC

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.456
Position:
61588305
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
24.157
Reference Allele:
A
-log10(P):
-295.185
MAF:
0.344
Beta (Num):
0.291
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.165
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid metabolism, Glycerophospholipid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Lysoplasmalogen pathway, Glycerophospholipid metabolism.7[1], 5[2], 8[3]

Ratio Explanation:

This ratio may reflect the activity of FADS1/FADS2, where higher activity could lead to increased synthesis of polyunsaturated phospholipids relative to plasmalogens.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by the ratio, is associated with altered lipid profiles, including cholesterol levels, potentially contributing to hypercholesterolaemia and indirectly influencing hormone-sensitive conditions like follicular cysts.1[1], 9[2], 10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data