1,2-dilinoleoyl-gpc (18:2/18:2) to sphingomyelin (d18:2/14:0, d18:1/14:1)*

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpc (18:2/18:2)
Metabolite Accession: GCST90200030
Name: 1,2-dilinoleoyl-gpc (18:2/18:2)
Hmdb Id: HMDB0008138
Super Pathway: NA
Sub Pathway: NA
Inchikey: FVXDQWZBHIXIEJ

Denominator Metabolite

Metabolite Accession: GCST90199975
Name: sphingomyelin (d18:2/14:0, d18:1/14:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.379
Position:
61557803
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
20.687
Reference Allele:
T
-log10(P):
-217.241
MAF:
0.347
Beta (Num):
0.288
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.090
SE (Den):
0.013
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phospholipid metabolism.8[1], 9[2], 10[3], 11[4], 12[5], 13[6]

Denominator Metabolite Explanation:

Sphingolipid metabolism.14[1], 9[2], 15[3], 16[4]

Ratio Explanation:

The ratio reflects the balance between glycerophospholipid synthesis and sphingolipid synthesis, influenced by FADS1/FADS2 activity which alters fatty acid availability for both pathways.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants influence the levels of polyunsaturated fatty acids, affecting the composition of both glycerophospholipids and sphingolipids.2[1], 17[2] This altered lipid profile is associated with variations in cholesterol levels18[3], 19[4], 20[5], 21[6], 22[7] and the risk for cholelithiasis and cardiovascular diseases.18[8], 3[9], 23[10], 24[11]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data