1,2-dilinoleoyl-gpc (18:2/18:2) to sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)*

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpc (18:2/18:2)
Metabolite Accession: GCST90200030
Name: 1,2-dilinoleoyl-gpc (18:2/18:2)
Hmdb Id: HMDB0008138
Super Pathway: NA
Sub Pathway: NA
Inchikey: FVXDQWZBHIXIEJ

Denominator Metabolite

Metabolite Accession: GCST90200033
Name: sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.366
Position:
61557803
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
19.918
Reference Allele:
T
-log10(P):
-201.576
MAF:
0.347
Beta (Num):
0.288
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.078
SE (Den):
0.014
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.4[1]

Denominator Metabolite Explanation:

Sphingolipid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio of a linoleic acid-containing phosphatidylcholine to specific sphingomyelins may reflect membrane composition dynamics influenced by FADS1/FADS2 enzyme activity on fatty acid precursors.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants alter PUFA synthesis, impacting membrane composition and inflammatory precursors.1[1], 7[2] This dysregulation of lipid mediators is linked to observed phenotypes like cholelithiasis and inflammatory conditions such as asthma, dermatitis, and inflammatory bowel disease.7[3], 8[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data