1,2-dilinoleoyl-gpc (18:2/18:2) to 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpc (18:2/18:2)
Metabolite Accession: GCST90200030
Name: 1,2-dilinoleoyl-gpc (18:2/18:2)
Hmdb Id: HMDB0008138
Super Pathway: NA
Sub Pathway: NA
Inchikey: FVXDQWZBHIXIEJ

Denominator Metabolite

Structure of 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Metabolite Accession: GCST90200041
Name: 1-palmitoyl-2-stearoyl-gpc (16:0/18:0)
Hmdb Id: HMDB0007970
Super Pathway: NA
Sub Pathway: NA
Inchikey: PZNPLUBHRSSFHT

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.506
Position:
61569830
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
28.474
Reference Allele:
C
-log10(P):
-408.949
MAF:
0.340
Beta (Num):
0.295
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.210
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid biosynthesis, Fatty acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Phospholipid biosynthesis, Fatty acid metabolism.4[1], 5[2]

Ratio Explanation:

The ratio of a phosphatidylcholine with polyunsaturated fatty acids to one with saturated fatty acids reflects the activity of FADS1/FADS2 enzymes.1[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in the FADS cluster influence desaturase activity, altering the balance of polyunsaturated to saturated fatty acids.1[1], 7[2] This imbalance is linked to dyslipidemia, cholelithiasis, and type 2 diabetes, which are causally associated with this metabolic signature.8[3], 9[4], 10[5], 11[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data