1,2-dilinoleoyl-gpc (18:2/18:2) to 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpc (18:2/18:2)
Metabolite Accession: GCST90200030
Name: 1,2-dilinoleoyl-gpc (18:2/18:2)
Hmdb Id: HMDB0008138
Super Pathway: NA
Sub Pathway: NA
Inchikey: FVXDQWZBHIXIEJ

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Metabolite Accession: GCST90200045
Name: 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Hmdb Id: HMDB0009003
Super Pathway: NA
Sub Pathway: NA
Inchikey: ANRKEHNWXKCXDB

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.515
Position:
61593005
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
21.501
Reference Allele:
A
-log10(P):
-234.440
MAF:
0.347
Beta (Num):
0.291
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.224
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

This ratio reflects the conversion efficiency of linoleic acid (18:2) to arachidonic acid (20:4), where a higher ratio suggests decreased FADS1/FADS2 enzyme activity.5[1], 6[2], 7[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by an elevated ratio, is associated with altered lipid profiles including cholesterol and triglycerides, and an increased risk for cholelithiasis and type 2 diabetes.5[1], 8[2], 9[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data