1,2-dilinoleoyl-gpc (18:2/18:2) to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpc (18:2/18:2)
Metabolite Accession: GCST90200030
Name: 1,2-dilinoleoyl-gpc (18:2/18:2)
Hmdb Id: HMDB0008138
Super Pathway: NA
Sub Pathway: NA
Inchikey: FVXDQWZBHIXIEJ

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Metabolite Accession: GCST90200058
Name: 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Hmdb Id: HMDB0005779
Super Pathway: NA
Sub Pathway: NA
Inchikey: URPXXNCTXCOATD

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.583
Position:
61569830
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
25.876
Reference Allele:
C
-log10(P):
-338.269
MAF:
0.340
Beta (Num):
0.295
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.287
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleate metabolism.14[1], 15[2], 16[3]

Denominator Metabolite Explanation:

Plasmalogen synthesis, Glycerophospholipid metabolism.17[1], 18[2], 19[3]

Ratio Explanation:

The ratio reflects the balance between glycerophospholipid and plasmalogen synthesis, with FADS1/2 potentially influencing the fatty acid substrates available for both pathways.1[1], 2[2], 20[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster are associated with altered polyunsaturated fatty acid levels and cholesterol metabolism, influencing the risk for hypercholesterolemia and cholelithiasis.21[1], 22[2], 23[3], 24[4], 25[5], 26[6], 27[7], 28[8], 29[9], 30[10] The ratio of these specific lipids may reflect this altered metabolism.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data