1,2-dilinoleoyl-gpc (18:2/18:2) to linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*

Numerator Metabolite

Structure of 1,2-dilinoleoyl-gpc (18:2/18:2)
Metabolite Accession: GCST90200030
Name: 1,2-dilinoleoyl-gpc (18:2/18:2)
Hmdb Id: HMDB0008138
Super Pathway: NA
Sub Pathway: NA
Inchikey: FVXDQWZBHIXIEJ

Denominator Metabolite

Structure of linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*
Metabolite Accession: GCST90200103
Name: linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*
Hmdb Id: HMDB0007257
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRECEGQUDDMNAQ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.607
Position:
61588305
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
25.423
Reference Allele:
A
-log10(P):
-326.634
MAF:
0.344
Beta (Num):
0.291
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.316
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Phosphatidylcholine biosynthesis.4[1]

Denominator Metabolite Explanation:

Glycerolipid metabolism, PUFA metabolism.5[1]

Ratio Explanation:

The ratio reflects FADS enzyme efficiency, comparing a lipid containing the precursor fatty acid (18:2) to one containing the product fatty acid, arachidonic acid (20:4).2[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters the production of arachidonic acid (20:4) from linoleic acid (18:2), reflected in the ratio.2[1], 3[2] This change in PUFA balance impacts lipid metabolism and inflammation, contributing to hypercholesterolemia, cholelithiasis, and related metabolic disorders.6[3], 7[4], 8[5], 9[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data